Crystal structure of a hypothetical protein, TT1725, fromThermus thermophilusHB8 at 1.7 Å resolution
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چکیده
منابع مشابه
Crystal structure of human CK2α at 1.06 Å resolution
The Ser/Thr kinase CK2 consists of two catalytic subunits (CK2α) and a dimer of the regulatory subunits (CK2β), and is a ubiquitous enzyme that regulates growth, proliferation and the survival of cells. CK2 is a remarkable drug target for potentially treating a wide variety of tumours and glomerulonephritis. The purified CK2α protein was crystallized using ethylene glycol as a precipitant. The ...
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Introduction. A large number of new protein structures have been determined by development of the field of structural genomics. Some of them are called “hypothetical proteins” due to missing information on their biological functions. In such cases, the three-dimensional structure is one of the important clues to infer the molecular function. TTHA0928 from Thermus thermophilusHB8 is a hypothetic...
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Mushroom tyrosinase-associated lectin-like protein (MtaL) binds to mature Agaricus bisporus tyrosinase in vivo, but the exact physiological function of MtaL is unknown. In this study, the crystal structure of recombinant MtaL is reported at 1.35 Å resolution. Comparison of its structure with that of the truncated and cleaved MtaL present in the complex with tyrosinase directly isolated from mus...
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Vibrio cholerae causes a severe disease that kills thousands of people annually. The outer membrane protein OmpU is the most abundant outer membrane protein in V. cholerae, and has been identified as an important virulence factor that is involved in host-cell interaction and recognition, as well as being critical for the survival of the pathogenic V. cholerae in the host body and in harsh envir...
متن کاملCrystal structure of Staphylococcus aureus peptidyl-tRNA hydrolase at a 2.25 Å resolution.
Peptidyl-tRNA hydrolase (Pth) catalyzes the release of tRNA to relieve peptidyl-tRNA accumulation. Because Pth activity is essential for the viability of bacteria, Pth is regarded as a promising target for the discovery of new antimicrobial agents. Here, the structure of Pth from the Gram-positive bacterium Staphylococcus aureus (SaPth) was solved by X-ray crystallography at a 2.25 Å resolution...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics
سال: 2003
ISSN: 0887-3585
DOI: 10.1002/prot.10412